Administration of Tim-1-blocking antibody inhibited activation of renal-infiltrated CD4+ helper and CD8+ cytotoxic T cells, reduced apoptosis of PTECs and protected against CDDP-induced AKI, indicating therapeutic and nephroprotective potential of Tim-1 that should be further explored in up-coming experimental and clinical studies [148]. The gene discussed is HAVCR1; the disease is acute kidney injury.