Although it has been reported that both local and systemic inflammatory processes mediated by adipocyte and macrophage FABP4/5 can cause such metabolic diseases [1, 2, 6, 7, 9, 10], it remains obscure how the simultaneous disruption of FABP4/5 in mice exhibits remarkable effects on the amelioration of metabolic diseases. Here, FABP4 is linked to metabolic disease.