The current study revealed that the pathomechanism by which the interaction of LCSLCs with HSCs induce stemness of HCC cells and pathologic-activated of HSCs via secreted high levels of IL-6 and HGF and the pharmacological mechanism underlying BrMC repress the secretion of IL-6 and HGF in Co-CM, thereby blocking the interaction between LCSLCs and HSCs. This evidence concerns the gene HGF and hepatocellular carcinoma.