Interestingly, we demonstrated that BrMC and chrysin attenuated the co-culture of LCSLCs and LX-2 cells induced the stemness of HCC cells, including SMMC-7721 and MHCC97H cells and pathological activation of LX-2 cells by inhibiting the secretion of IL-6 and HGF. Here, IL6 is linked to hepatocellular carcinoma.