After Oncoscore analysis we selected the top 7 genes (strongly associated with cancer: WT1, BCL9, SMYD3, ZNF154, ZNF177, HOXD9, and ITIH5) and the bottom 7 genes (no published association with cancer: TMEM132C, TDRD10, RNF220, RIMBP2, PRAC2 (C17orf93), EFCAB1, and ANKRD53) for further analysis of diagnostic and prognostic potential (Fig. 3). This evidence concerns the gene SMYD3 and cancer.