Sites cg01268824 (ZNF154), cg22674699 (HOXD9), cg18081940 (TDRD10), and cg04475027 (TMEM132C) localized to gene promoter regions, were hypermethylated, and were negatively correlated with expression in breast tumor tissue, suggesting that DNA methylation at these sites may silence gene transcription (Table 1). The gene discussed is TDRD10; the disease is breast neoplasm.