CREB1 and cancer: However, β2M expression had no significant correlation with HIF-1α, p-CREB, VEGF, p-SGK1, p-ERK1/2, and Bcl-2 (p > 0.05), except that VEGF showed a strong positive correlation with Bcl-2 (r = 0.599, p = 0.000) in cancer tissues of patients with basal-like breast cancer (Table 5).