The expression of β2M, VEGF, and Bcl-2 were significantly higher in cancer tissues of patients with basal-like breast cancer (p < 0.05), and no significant differences in expression of HIF-1α, p-CREB, p-SGK1, and p-ERK1/2 were detected between cancer tissues and their matched adjacent tissues (p > 0.05; Fig. 4b and Table 4). The gene discussed is CREB1; the disease is breast cancer.