Among two studies evaluating Sod2, increased methylation of a single CpG site in the first intron (+ 128 from TSS) of Sod2 was associated with increased cardio-respiratory dysfunction and hypertension when rats were exposed to intermittent hypoxia (IH) neonatally [43], and methylation of a single dinucleotide in CpG region 4, + 157 bp from the transcription start site (TSS) was positively associated with hypertension when rats were exposed to IH as adults [40]. Here, SOD2 is linked to hypertensive disorder.