Those risk genes involved in cholesterol metabolism, such as CLU, ATP-binding cassette subfamily A member 7 (ABCA7), and SORL1, may also be associated with hyperlipidemia; those risk genes involved in immune response, such as CR1, CD33, MS4A, TREM2, and CLU, may also be associated with diseases related to the immune system [192]. The gene discussed is CLU; the disease is hyperlipidemia.