SNCA and Parkinson disease: PD is a neurodegenerative disorder that has long been thought to typically affect the motor system, in particular the nigra-striatal pathway, characterized by dopaminergic neuron loss in nigra-striatal area and accumulation of intraneuronal proteinacious inclusions named Lewy Bodies (LBs) and Lewy neurites made of alpha-synuclein (αS) [58].