Since upon degranulation serine proteases such as tryptase are the major constituent of secretory granules released by mast cells, in addition to cytokines, growth factors and other bioactive molecules [15], we focused on the transforming growth factor-β (TGF-β) signalling and on the G protein-coupled receptor proteinase-activated receptor 2 (PAR2) pathway, that in response to activation by serine proteinases, such as tryptase, drives the progression of pancreatic cancer. The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.