The loss of let-7b increased the expression of basigin (BSG, CD147) and enhanced MMP (matrix metalloproteinase) production, whereas its overexpression suppressed proliferation, invasion, migration, and colony formation in the B16-F10 melanoma cell line and reduced the number of tumour nodules found in the lungs of mice intravenously injected with let-7b-transfected B16-F10 cells [119]. The gene discussed is BSG; the disease is neoplasm.