HIF3A and cancer: In summary, we identified and validated eight top candidate markers (DOCK2, FBXO30, HIF3A, GRASP, MOB3B, PFKP, TPM4 and cg12799885) that were significantly hypermethylated in PCa compared to non-malignant prostate tissue samples, as well as to other cancer types, and which were essentially unmethylated in the PBC samples, together indicating promising diagnostic potential.