Specifically, three previous tissue-based studies reported promising diagnostic potential for HIF3A, GRASP, MOB3B and/or TPM4 hypermethylation in PCa with AUCs ranging from 0.93–0.99 [15,21], which is comparable to our current results (AUC range: 0.91–0.95). The gene discussed is HIF3A; the disease is posterior cortical atrophy.