Moreover, in The Cancer Genome Atlas (TCGA) PCa patient dataset (n = 532 with RNAseq and 450K data available), we found a significant inverse correlation between transcriptional gene expression and the DNA methylation levels for DOCK2, FBXO30, GRASP, HIF3A, MOB3B, PFKP and TPM4 (p < 0.001; rho: 0.33–0.64; Supplementary Figure S4). Here, TAMALIN is linked to posterior cortical atrophy.