This approach identified seven candidate PCa-specific hypermethylation markers (cg12799885, C2orf43, C2orf88, FBXO30-cg23095615, FBXO30-cg09094393, MOB3B and TPM4), all of which were suitable for the qMSP assay design and were selected for further validation (see Section 2.2 below). The gene discussed is TPM4; the disease is posterior cortical atrophy.