In summary, we identified and validated eight top candidate markers (DOCK2, FBXO30, HIF3A, GRASP, MOB3B, PFKP, TPM4 and cg12799885) that were significantly hypermethylated in PCa compared to non-malignant prostate tissue samples, as well as to other cancer types, and which were essentially unmethylated in the PBC samples, together indicating promising diagnostic potential. Here, TAMALIN is linked to cancer.