Furthermore, except for DOCK2, all of the genes were significantly downregulated in PCa (n = 497) compared to the AN (n = 35) tissue samples in the TCGA set (p ≤ 0.001, Wilcoxon Mann–Whitney test, Supplementary Figure S4), consistent with hypermethylation-based epigenetic gene silencing. The gene discussed is DOCK2; the disease is posterior cortical atrophy.