For example, a GATA3 motif was identified through analysis of TCF7L2 ChIP-seq peaks from breast cancer cells [65]; follow-up studies demonstrated that GATA3 and TCF7L2 interact with each other and that depletion of GATA3 in breast cancer cells reduces binding of TCF7L2 to specific sites. The gene discussed is GATA3; the disease is breast cancer.