An unbiased analysis of DNA methylation and gene expression data using a large set of tumors from TCGA identified HOXB13, HOXC4, HOXC5, and HOXC6 in the set of the top 10 transcription factors whose expression is linked to the creation of newly active distal regulatory elements in prostate cancers [23]. Here, HOXB13 is linked to Familial prostate cancer.