Specifically, depletion of HOXB13 decreased proliferation of cancer cells [30], siRNA-mediated reduction of HOXC6 reduced proliferation of prostate cancer cells [34], siRNA knockdown of HOXB13 reduced cell growth and migration of prostate cells in response to androgen treatment [27], and siRNA knockdown of HOXD9 reduced glioma cancer proliferation and colony formation but increased apoptosis [70]. This evidence concerns the gene HOXD9 and Familial prostate cancer.