Interestingly, CD133+ stem-cell subpopulations from the human NB cell lines SK-N-SH and SK-N-BE displayed high resistance to pro-apoptotic chemotherapeutic agents, in association with DUSP1 protein low expression levels and high phosphoERK1/2 (pERK1/2) and phosphop38 (pp38) content, suggesting that DUSP1 expression, at least in some NB cell populations, may facilitate chemotherapy efficacy [63]. The gene discussed is PROM1; the disease is neuroblastoma.