On the other hand, the variable effects of JNK and p38 MAPKs on NB cell apoptosis endorse the possibility of a beneficial use of inhibitors of JNK- or p38-specific MKPs, such as DUSP1, DUSP8, DUSP10, or DUSP16, but only in NB cases in which the activity of JNKs or p38s favors tumor chemosensitivity. This evidence concerns the gene MAPK8 and neoplasm.