On the other hand, the variable effects of JNK and p38 MAPKs on NB cell apoptosis endorse the possibility of a beneficial use of inhibitors of JNK- or p38-specific MKPs, such as DUSP1, DUSP8, DUSP10, or DUSP16, but only in NB cases in which the activity of JNKs or p38s favors tumor chemosensitivity. The gene discussed is DUSP1; the disease is neuroblastoma.