ANGPT1 and male reproductive organ cancer: Supplementation of exogenous Ang-1 was found to partially restore both CSC (CD49f and Bmi-1) and quiescence marker (p27) expression in γ-T3-treated prostate cancer cells (Figure 1C), suggesting that the inhibitory effect of γ-T3 on the stemness of prostate CSCs is through the suppression of the Ang-1/Tie-2 signalling pathway.