TEK and Familial prostate cancer: Similarly, treatment of C42B cells with both compounds (10 μg/mL γ-T3 and 5 μM Tie-2 inhibitor) together, but not with either compound alone, was found to suppress cell viability (Figure 2C–E), suggesting that γ-T3 and Tie-2 inhibitor work synergistically in suppressing the survival of prostate cancer cells.