MMP2 and melanoma: As a result, the inhibition of these signaling pathways led to a reduction in the expression of microphthalmia-associated transcription factor (MITF), which is an important regulator of melanogenesis and malignant melanoma development, as well as matrix metalloproteinase (MMP)-2 and MMP-9, which play a critical role in melanoma metastasis (Figure 8A) [23,24].