RAC1 and neoplasm: We also showed that ncRNA00201 is able to modulate pathways that are associated to both SSc and tumor development such as EGF receptor, ErbB1 downstream, S1P1, Arf6 downstream, ALK1, Endothelins, RhoA, Class I PI3K, mTOR, p38 MAPK, RAC1, TGF-beta receptor, MyD88 and Toll-like receptors signaling pathways, confirming our previous observations [6].