NR2F1 and breast carcinoma: A series of C-DIMs containing heteroaromatic substituents was also prepared, and the results in Figure 1A summarize the effects of heteroaromatic C-DIMs on activation of COUP-TFI in MCF-7 breast cancer cells transfected with GAL4-COUP-TFI (full length) and a reporter construct (GAL4-luc) containing 5 tandem GAL4 response elements.