Overexpression of COUP-TFI in rat urogenital mesenchymal (rUGM) cell lines resulted in induction of Egr-1 (27), and results in Figure 5A,B show that 5 μM DIM-C-Pyr-4 induced Egr-1 protein in MCF-7 and ZR-75 breast cancer cells, respectively. The gene discussed is NR2F1; the disease is breast cancer.