Also in CTCL, DKP-071 mediated its proapoptotic effects via activation of the extrinsic caspase cascade, as shown by caspase-8 and caspase-3 processing as well as by the inhibition of the effects of indirubin through the caspase-3 antagonist QVD-Oph. The gene discussed is CASP8; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.