We also found several CNVs that included the genes HNRNPU (1q44) and RORB (9p21.13), both recently associated with epilepsy.28, 30, 31, 32 Microdeletions of the 1q43q44 critical region have been associated with ID, dysmorphism, abnormalities of the corpus callosum, and seizures.30 This critical region includes HNRNPU as the most relevant candidate epilepsy gene. This evidence concerns the gene HNRNPU and epilepsy.