Interestingly, several of these L2b-targets, which are not bound by AGO2 in glioblastoma, are implicated in glioma, such as PCDH9 [22] and AQP4 [19] and show similar non-canonical target sites as we found in other L2-miRNA targets (Fig 6I). This evidence concerns the gene AQP4 and central nervous system cancer.