Genome-wide association studies have linked AMD to several genes involved in generation and remodeling of high-density lipoproteins (HDLs), namely ATP-binding cassette transporter A1 (ABCA1), apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP) and hepatic lipase C (LIPC) (Fritsche et al., 2016). Here, APOE is linked to age-related macular degeneration.