ABCA1 and age-related macular degeneration: Two SNPs in intron 2 of the human ABCA1 gene (rs1883025 and rs2740488), which are in high linkage disequilibrium (r2 = 0.941), have been associated with AMD (Chen et al., 2010; Fauser et al., 2011; Peter et al., 2011; Yu et al., 2011; Fritsche et al., 2016).