In multivariate logistic regression, while comparing between HIV patients with and without hepatotoxicity, CYP2B6 516TT genotype showed a risk for ARV‐associated hepatotoxicity (OR = 1.79, p = 0.27).It supports the idea that individuals with CYP2B6516TT genotype and alcohol and nevirapine usage are more prone to alcohol and drug‐related hepatotoxicity. The gene discussed is CYP2B6; the disease is hepatotoxicity.