While comparing between HIV patients with and without hepatotoxicity, CYP2B6 516TT genotype, taking alcohol and male HIV patients with hepatotoxicity showed a risk for ARV‐associated hepatotoxicity (OR = 1.79, p = 0.27; OR = 1.91, p = 0.63; OR = 1.90, p = 0.16, respectively)  (Table 8). Here, CYP2B6 is linked to hepatotoxicity.