TFEB and early-onset autosomal dominant Alzheimer disease: Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD) are neurodegenerative diseases featured with the accumulation of specific mutant protein aggregates and protein degradation disorders.38 As an “intracellular garbage treatment station,” lysosomal dysfunction is associated with these neurodegenerative diseases.11, 32, 39, 40, 41, 42, 43 Upregulation of TFEB regulates the autophagy to improve cell clearance and thus becomes a treatment for lysosomal storage disorders (LSD)44 and delays the process of Alzheimer's disease45 and other neurological diseases.16, 18, 46