Multivariable analysis presented that tumor number (hazard ratio (HR)=1.238, 95% CI: 1.095‐1.400, P = 0.002), alpha‐fetoprotein (AFP) (HR = 1.485, 95% CI:1.237‐1.783, P < 0.001), and the type of initial treatment (HR = 1.497, 95% CI: 1.328‐1.688, P < 0.001) was the significant factors for OS (Table S7). This evidence concerns the gene AFP and neoplasm.