Indeed, decreased levels in cellular cholesterol after knockdown of the peroxisome‐ER tethering protein ACBD5 may point to such a central position in cholesterol trafficking.35 Mutations in VAPB have been linked to amyotrophic lateral sclerosis (ALS).15 As ALS patients carrying a VAPB (P56S) mutation are reported to have increased cholesterol levels,138 it was speculated that this increase may be caused by increased ER‐peroxisome contacts.35 Further studies on a possible role of the ER‐peroxisome tethering in the pathogenesis of ALS are required. Here, PROS1 is linked to amyotrophic lateral sclerosis.