DHA deficiency results in memory loss, learning disabilities, and impaired vision.113 In patients with ACOX1‐ and DBP‐deficiency and subsequent defects in peroxisomal β‐oxidation, DHA is known to be decreased.111 Interestingly, DHA/DHA‐containing phospholipids are also required for the plasticity and membrane dynamics of peroxisomes, for example, for membrane elongation and division.114 In a recent lipidomics study, a variety of phospholipid species containing PUFAs (including DHA) were found to be decreased in ACOX1‐ and DBP‐deficient fibroblasts, but not in fibroblasts from ALD patients. Here, DBP is linked to learning disability.