SOD1 and amyotrophic lateral sclerosis: Although the involvement of wild-type SOD1 (SOD1WT) in ALS is contentious [9, 17, 27], there is an increasing body of evidence that has identified the presence of disordered and aggregated SOD1 in motor areas of the CNS in ALS patients that lack SOD1 mutations [15, 31, 32, 33, 39, 56, 60, 62].