CD274 and neoplasm: In fact, gene expression analysis of a tumor treated with a combination of Abemaciclib and anti-PD-L1 showed enrichment of genes in dendritic cell (DC) maturation; this observation indicates that combination treatment may directly or indirectly affect immunological events beyond T cell activation and may modulate innate immune mechanisms resulting in enhanced antigen presentation and T cell priming (Schaer et al., 2018).