In addition, combination of abemaciclib with anti-PD-L1 resulted in a markedly tumor inflamed phenotype shown by greater than twofold upregulation of multiple T cell activation-associated genes encoding IFNγ, co-inhibitory receptors and ligands (PD-1, PD-L1, PD-L2, LAG3, VISTA), cytokines and chemokines (IL10, TNFα, MIP1α, MIP1β, RANTES, GRO), and IFNγ-dependent enzymes (IDO1, iNOS). Here, CD274 is linked to neoplasm.