Out of the 16 significantly upregulated genes in our analysis of clear cell RCC, we could confirm the increased expression of 8 genes in the GSE6344 dataset, including VEGFA, BIRC5, VIM, CCND1, MYC, CDKN1A, CDK1, and BCL2. Among the nine downregulated genes in clear cell carcinoma, three gene including STMN1, HIF1A, and MUC1 could be confirmed in this new dataset. The gene discussed is BCL2; the disease is clear cell adenocarcinoma.