We explored the most well–characterized 32 STAT3-regulated genes involved in cancer cell invasion (CDH1, ICAM1, ITGB4, ITGB6, MUC1, PTK2, STMN1) (8, 12, 17–19); cell proliferation (CCND1, CCNB1, CDC25A, MYC, PIM1, PIM2, CDK1, CDKN1A, JUN, FOS) (8, 20–22); cell survival (BCL2, BCL2L1, BIRC5, MCL1) (23); angiogenesis (VEGF, HIF1A, FGF2) (8, 24); metastasis (TWIST1, MMP-1,−2,−9, VIM) (8, 12); and inflammation (IL1B, IL6, CSF1) (8, 25) (Figure 1). Here, PIM1 is linked to cancer.