ICAM1 (intracellular adhesion molecule 1) was upregulated in clear cell, unchanged in papillary, and downregulated in chromophobe; while ICAM1 expression is linked to increased leukocyte infiltration of RCC tumors, much is still unknown about endothelial activation and RCC disease progression (52, 53). The gene discussed is ICAM1; the disease is renal cell carcinoma.