LPL and pancreatitis: When HTG is caused by rare monogenetic mutations in genes like lipoprotein lipase (LPL) [8], the main enzyme that hydrolyzes plasma TG, or apolipoprotein C-II (apoC-II) [9], an activator of LPL, larger lipoprotein TG-rich particles tend to accumulate and these patients are at a risk for pancreatitis [10].