To identify the potential TSPX downstream gene in clinical prostate cancer, we had analyzed the differential gene expression patterns of LNCaP cells overexpressing TSPX versus EGFP (Figure 4A) and those of TSPX-high group versus TSPX-low group in clinical prostate cancer samples from TCGA datasets (Figure 5B). The gene discussed is TSPYL2; the disease is Familial prostate cancer.