Importantly, the expression levels of these genes were closely correlated with those of TSPX expression in the prostate cancer specimens, i.e. TSPX-low, TSPX-mid, and TSPX-high respectively (Figure 5G), suggesting that the regulatory effects of TSPX on its targets in prostate cancer could be dosage dependent. The gene discussed is TSPYL2; the disease is prostate cancer.