Indeed, a prostate cancer susceptibility locus (loci) has been mapped on Xp11.2 associated with the SNP rs5945572 [8], adjacent of which multiple tumor suppressor genes, including FOXP3 and AMER1 (also known as WTX and FAM123B), are located [7, 9, 10]. The gene discussed is AMER1; the disease is Familial prostate cancer.