The first enzyme—LOX—is a prooxidant agent belonging to the family of lipoxygenases, enzymes catalysing the incorporation of dioxygen molecules into polyunsaturated fatty acids and formation of key chemokines and ROS, such as leukotrienes and O2∙–, associated with the development of numerous NCDs, e.g., atherosclerosis, myocardial infarction/reperfusion injury, rheumatoid arthritis, and cancer [56]. The gene discussed is LOX; the disease is rheumatoid arthritis.