For example, literature had suggested the following possible signaling molecules or pathways: hypoxia exposure regulated the expression of lysyl oxidase and other target genes via promotion of HIF-1; the HIF-1/Angptl4 pathway may play a vital role in CIH-mediated abnormal lipid metabolism and even atherosclerosis formation; and SREBPs, which are closely related to glycolipid metabolism, might be related to CIH-mediated insulin resistance. This evidence concerns the gene HIF1A and Insulin resistance.