The rs35068180 located in the gene that codes for the matrix metalloprotease 3 (also known as Stromelysin 1) has been related to diabetic nephropathy (Kure et al., 2011), and its combination with the rs1799750 located in the MMP1 gene strongly associates to end stage renal disease (Cozzolino et al., 2009). The gene discussed is MMP1; the disease is stage 5 chronic kidney disease.