Those disturbances occur very early in CKD [increases in Fibroblast Growth Factor 23 have been described from CKD stage 2 (Wolf, 2012)], have a high impact in outcomes (Valdivielso et al., 2017) and, furthermore, are associated with CKD progression (Schwarz et al., 2006). This evidence concerns the gene FGF23 and chronic kidney disease.