XCL1 and neoplasm: In both of our tumor models, the frequencies and functionality of tumor infiltrating T cells as well as associated tumor control were similar, whether the OVA SLP was fused with the Xcl1-Fc or was co-delivered, which suggests that the signaling machinery induced by the internalization of the cargo via the Xcr1 receptor was instrumental for efficient antigen internalization and processing for MHC class I-mediated presentation.