One of the key requirements for successful therapeutic cancer vaccinations relies on the ability to target antigen to cross-presenting dendritic cells (DCs), a subtype of DCs which have the capacity to shunt a proportion of internalized antigens from the endosomal compartments to the cytosol, where they are processed for loading onto MHC class I molecules, resulting in efficient CD8+ T cell responses (1). Here, CD8A is linked to cancer.