While HCMV-specific CD8+ T cell responses do not themselves exhibit functional impairment in HIV+ART+ individuals (22), HCMV infection may indirectly impact CD8+ T cell immunoscenescence through ongoing production of proinflammatory cytokines and by limiting T cell receptor diversity across the broader CD8+ T cell population (22, 59). Here, CD8A is linked to cytomegalovirus infection.