C2 and systemic lupus erythematosus: The same rationale could be applied to the other SLE associated genes by common variation also detected as targets by rare variation with SKAT but not by burden test in our study (Supplemental Tables 1, 4): GTF2IRD1 (39, 42), DAB2 (41), NOTCH4 (37), CLEC16A (32, 42, 44), TNFSF4 (32, 40–46), and C2 (36).