The same can be argued for DOCK8 (ORburden.test = 2.33, P SKAT.corr = 0.03 and Pburden.test.corr = 0.204) the cause of Hyper-IgE recurrent infection syndrome (HIES) autosomal recessive by homozygous or compound heterozygous mutation (OMIM #243700). Here, DOCK8 is linked to hyper-IgE syndrome.