PSMB8 and lipodystrophy: Autoinflammation, lipodystrophy, and dermatosis syndrome (ALDD) can be caused by homozygous mutations in the PSMB8 gene (OMIM: # 256040), P SKAT.corr = 0.0246 and Pburden.test.corr = 0.00179, ORburden.test = 0.64 and CI 95%.burden.test = (0.48, 0.84).