Focusing on the best-hits which meet the criteria of simultaneous significant association in both rare variation tests, SKAT and burden test, we found some genes described as associated with SLE by common variation such as TMEM55B (46), SPATA8 (36), PRDM1 (32, 40, 42, 44, 48), and HLA-DRB1 (36, 40, 42, 43, 45) (Table 3). This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.