TMEM106B [P SKAT.corr < 1.00E-03 and Pburden.test.corr = 0.0177, ORburden.test = 0.56 and CI95%.burden.test = (0.38, 0.82)] was associated with frontotemporal dementia (71, 72). This evidence concerns the gene TMEM106B and frontotemporal dementia.