GCG and osteoporosis: However, despite a strong inhibition of osteoclast activity and a significant increase in aBMD after 4 months treatment (17), GLP-2 has not reached the market as a new drug for the treatment of osteoporosis, although a GLP-2 analog (teduglutide) was approved by FDA in 2012 for the treatment of SBS because of its beneficial effects on intestinal function (63).