Besides TDP-43 and FUS, many additional proteins are under investigation as potential participants in ALS pathogenesis, including heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), hnRNPA2B1, hnRNPA3, TAF15, and EWSR1 (Neumann et al., 2011; Ugras and Shorter, 2012; Thomsen et al., 2013; Le Ber et al., 2014). This evidence concerns the gene HNRNPA1 and amyotrophic lateral sclerosis.