SLC25A13 and Hyperammonemia: To further identify specific amino acids that may be most effective in altering the hyperammonemia in CTLN2 patients, we tested the candidate amino acids that were found to be most effective at both decreasing hepatic G3P and increasing hepatic Asp content within the context of this new induced hyperammonemic state (Fig. 1(a,b)): namely Ala, Glu, Orn and Asp.