Botulinum neurotoxin A (BoNT/A) binds to a ganglioside and a synaptic vesicle protein SV2A/B/C, BoNT/B binds to a ganglioside and a synaptic vesicle protein Synaptotagmins I/II while Tetanus neurotoxin binds to dual-gangliosides30,31. The gene discussed is SYT1; the disease is tetanus.