This cell line was originally derived from the bone marrow of a 50-year-old woman with B-acute lymphoblastic leukemia, that carries the three-way-translocation t(8;14;18) and overexpress Bcl2 and c-Myc, translocations that are associated with poor clinical prognosis51,52. The gene discussed is MYC; the disease is acute lymphoblastic leukemia.