TNFRSF1A and neoplasm: Overall, we observed that TH17 cells and their signature cytokines are increased in the injured livers of Tnfr1−/−/Mdr2−/− mice (Fig. 3), while hepatic gene expression of markers of regeneration and possibly tumour development appeared to be rather activated rather than impaired in the absence of TNFR1 (Supplementary Fig. 3).