CREBBP and Nematoda infectious disease: The higher expression of both CaMK2 and Crebbp as well as the Ca2+signaling pathway itself in the brain of P7 pups of nematode-infected dams indicates up-regulated Ca2+ signalling, and furthermore, down-regulation of protein phosphatase kinases which suppress long-term memory23 supports the observation that maternal nematode infection exerts a positive influence on the developing brain of the pups.