It has been known for a long time that SOCS proteins play an important part in the fine tuning of the immune response and inflammation16 being involved in inflammatory diseases as CeD or T1D, the inflammation-related variability of the m6A methylation in these transcripts, and other interesting candidates, could provide progress on the understanding on their contribution in disease pathogenesis. The gene discussed is CISH; the disease is cranioectodermal dysplasia.