For example, in a US study, VEGFR-1 was detected in primary CRC and hepatic metastases, but not in nonmalignant mucosa18; while, VEGFR-2 and VEGFR-3 correlated with invasive adenocarcinoma and hepatic metastasis, respectively, in Portugal CRC patients9. The gene discussed is FLT1; the disease is colorectal carcinoma.