CRK and cancer: Of these 35 ‘cancer’ genes, 23 were upregulated and hypomethylated, with a large proportion of these genes (13 out of 23) known to be important in matrix/actin structure and remodelling as well as mechano-transduction in skeletal muscle including: MSN, THBS1, TIMP3, FLNB, LAMA5, CRK, COL4A1, ITGA2, ITGB3, CD63, CTTN, RASSF5, F2RL3 (full gene names and general function is included in (Suppl.