FLNB and cancer: Finally, Filamin B (FLNB) was identified in the ‘cancer’ pathway (with a role in the actin cytoskeleton) in both acute RE and chronic RE transcriptomic analysis above, as well as being identified in the 51 genes significantly modified across transcriptome and methylome analysis, and further identified in the final 5 genes above with increased gene expression as well as hypomethylation (with retained methylation during detraining and retraining).