Sema3A positively regulate Wnt/β-catenin signaling in osteoblasts27, whereas osteosarcoma-derived Sema3A suppresses Wnt/β-catenin signaling50, suggesting that the effect of Sema3A on the Wnt/β-catenin signaling might depend on cell context. The gene discussed is SEMA3A; the disease is osteosarcoma.