Colon histologies showed immune cell infiltration, epithelial hyperplasia and goblet cell depletion in Rag1–/– mice 12 weeks after co-transfer of Stim1/2-deficient Treg cells, whereas host mice co-transplanted with WT Treg cells showed no obvious signs of IBD (Supplementary Figure 2e). This evidence concerns the gene STIM1 and inflammatory bowel disease.