Abolished GATA3, IRF4, and BATF expression in Stim1/2-deficient Tregs may thus explain the type 2 autoimmunity in Stim1/2Foxp3 mice, which is characterized by elevated Th2 cytokines, increased IgE levels and eosinophilia. Here, STIM1 is linked to Increased total eosinophil count.