Dissection of male Stim1/2Foxp3 mice revealed splenomegaly and lymphadenopathy with significantly enlarged submandibular, inguinal, and axillary LNs compared to WT littermate controls, whereas mesenteric LNs were less enlarged (Fig. 2a, Supplementary Figure 1c, d). This evidence concerns the gene STIM1 and Lymphadenopathy.