Interestingly, INSIG1 is also involved in regulating cholesterol in the cell, and genetic association studies suggests it has potential links to Alzheimer’s based a reported trend level genomewide association (p = 7 × 10−7) of an INSIG1 3’ untranslated region SNP to Alzheimer’s Disease in a family based association study46,50. This evidence concerns the gene INSIG1 and early-onset autosomal dominant Alzheimer disease.