LMNA and heart disorder: Our work also demonstrates that treatment with TUDCA, previously proven to efficiently alleviate ER stress in experimental diabetes (Ozcan et al, 2006), aortic valve calcification (Cai et al, 2013), and cardiac disease (Rivard et al, 2007; Rani et al, 2017), markedly ameliorated vascular pathology in the fat‐fed mouse models with ubiquitous and VSMC‐specific progerin expression (Apoe−/−LmnaG609G/G609G and Apoe−/−LmnaLCS/LCSSM22αCre mice, respectively).