LMNA and Hutchinson-Gilford progeria syndrome: However, only a few studies have investigated the molecular alterations caused by progerin accumulation in VSMCs (Zhang et al, 2011, 2014; Villa‐Bellosta et al, 2013; Hamczyk et al, 2018a), and none analyzed it in the context of atherosclerosis, the main death‐causing symptom of HGPS, due to lack of adequate animal models.