To this end, we used two mouse models of HGPS, with progerin expressed either ubiquitously (Apoe−/−LmnaG609G/G609G) or restricted to VSMCs (Apoe−/−LmnaLCS/LCSSM22αCre), which fully recapitulate the vascular phenotype observed in HGPS patients (Olive et al, 2010; Hamczyk et al, 2018b). This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.