Given the importance of VSMCs in progerin‐driven cardiovascular disease (Stehbens et al, 2001; Olive et al, 2010; Hamczyk et al, 2018b), we sought to identify mechanisms underlying VSMC death and enhanced atherosclerosis in HGPS, which seem to be independent of elevated cholesterol levels in the blood (Gordon et al, 2005; Hamczyk et al, 2018b). The gene discussed is LMNA; the disease is atherosclerosis.