However, only a few studies have investigated the molecular alterations caused by progerin accumulation in VSMCs (Zhang et al, 2011, 2014; Villa‐Bellosta et al, 2013; Hamczyk et al, 2018a), and none analyzed it in the context of atherosclerosis, the main death‐causing symptom of HGPS, due to lack of adequate animal models. This evidence concerns the gene LMNA and atherosclerosis.